Soft Tissue Sarcoma

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Fusion genes: Ewing sarcoma: t(11;22)(q24;q12) EWS-FLI1 t(21;22)(q22;q12) EWS-ERG t(7;22)(p22;q12) EWS-ETV1 others FUS-ERG, EWS-FEV, Desmoplastic SRCT: t(11;22)(p13;q12) EWS-WT1 Extraskel myxoid chondrosarc: t(19;22)(q22;q12) EWS-TEC(CHN) Malignant mesenchymoma: t(11;22)(q24;q12) EWS-FLI1 Alveolar rhabdomyosarcoma: t(2;13)(q35;q14) PAX3-FKHR t(1;13)(p36;q14) PAX7-FKHR Myxoid round cell liposarcoma: t(12;16)(q13;p11) CHOP-TLS (FUS) Others EWS-CHOP (DDIT3) Synovial sarcoma: t(X;18)(p11.2;q11.2) SYT-SSX1 Clear cell sarcoma: t(12;22)(q13-14;q12) EWS-ATF1 Others FUS-ATF1, EWS-CREB1 Uterine leiomyoma: t(12;14)(q15;q23-24) HMGIC-RAD51B Same gene translocation in different tumor cells give rise to distinct tumors...

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تاریخ انتشار 2008